Phenylboronic / Boronic acid CAS NO. 864759-63-7, CAS NO. 98-80-6

Factory supply Phenylboronic/ Boronic acid CAS NO. 864759-63-7, CAS NO. 98-80-6.
Buy Phenylboronic acid CAS-864759-63-7 CAS-98-80-6. Factory supply Phenylboronic/ Boronic acid CAS NO. 864759-63-7, CAS NO. 98-80-6. Buy Phenylboronic acid CAS-864759-63-7, CAS-98-80-6. Phenylboronic acid for sale or benzeneboronic acid for sale, abbreviated as PhB(OH)2 where Ph is the phenyl group C6H5-, is a boronic acid containing a phenyl substituent and two hydroxyl groups attached to boron. Phenylboronic acid is a white powder and is commonly used in organic synthesis. Boronic acids are mild Lewis’s acids which are generally stable and easy to handle, making them important to organic synthesis. Buy Phenylboronic acid CAS-864759-63-7 CAS-98-80-6
Phenylboronic acid is soluble in most polar organic solvents and is poorly soluble in hexanes and carbon tetrachloride. This planar compound has idealized C2V molecular symmetry. The boron atom is sp2-hybridized and contains an empty p-orbital. The orthorhombic crystals use hydrogen bonding to form units made up of two molecules. These dimeric units are combined to give an extended hydrogen-bonded network. The molecule is planar with a minor bend around the C-B bond of 6.6° and 21.4° for the two PhB(OH)2 molecules. Buy Phenylboronic acid CAS-864759-63-7 CAS-98-80-6
Synthesis Buy Phenylboronic acid
Numerous methods exist to synthesize phenylboronic acid. One of the most common syntheses uses phenylmagnesium bromide and trimethyl borate to form the ester PhB(OMe)2, which is then hydrolyzed to the product. Other routes to phenylboronic acid involve electrophilic borates to trap phenylmetal intermediates from phenyl halides or from directed ortho-metalation. Phenylsilanes and phenylstannanes transmetalate with BBr3, followed by hydrolysis form phenylboronic acid. Aryl halides or triflates can be coupled with diboronyl reagents using transition metal catalysts. Aromatic C-H functionalization can also be done using transition metal catalysts. Buy Phenylboronic acid CAS-864759-63-7 CAS-98-80-6
Reactions Buy Phenylboronic acid
The dehydration of boronic acids gives boroxines, the trimeric anhydrides of phenylboronic acid. The dehydration reaction is driven thermally, sometimes with a dehydration agent. Buy Phenylboronic acid CAS-864759-63-7 CAS-98-80-6
Triphenyl boroxine synthesis Buy Phenylboronic acid
Phenylboronic acid participates in numerous cross coupling reactions where it serves as a source of a phenyl group. One example is the Suzuki reaction where, in the presence of a Pd(0) catalyst and base, phenylboronic acid and vinyl halides are coupled to produce phenyl alkenes. This method was generalized to a route producing biaryls by coupling phenylboronic acid with aryl halides. Buy Phenylboronic acid CAS-864759-63-7 CAS-98-80-6
C-C bond forming processes commonly use phenylboronic acid as a reagent. Alpha-amino acids can be generated using the uncatalyzed reaction between alpha-ketoacids, amines, and phenylboronic acid. Heck-type cross coupling of phenylboronic acid and alkenes and alkynes has been demonstrated. Buy Phenylboronic acid CAS-864759-63-7
Aryl azides and nitroaromatics can also be generated from phenylboronic acid. Phenylboronic acid can also be regioselectively halodeboronated using aqueous bromine, chlorine, or iodine:Buy Phenylboronic acid CAS-864759-63-7 CAS-98-80-6
Boronic esters result from the condensation of boronic acids with alcohols. This transformation is simply the replacement of the hydroxyl group by alkoxy or aryloxy groups. This reversible reaction is commonly driven to product by the use of Dean-Stark apparatus or a dehydration agent to remove water.
As an extension of this reactivity, PhB(OH)2 can be used as a protecting group for diols and diamines. This reactivity is the basis of the use of phenylboronic acid’s use as a receptor and sensor for carbohydrates, antimicrobial agents, and enzyme inhibitors, neutron capture therapy for cancer, transmembrane transport, and bioconjugation and labeling of proteins and cell surface.
Quick Details Buy Phenylboronic acid
Classification: Pharmaceutical Intermediates
Cas NO.: 98-80-6
Name: Phenylboronic acid
Molecular Formula: C6H7BO2
Melting Point: 217-220℃
Boiling Point: 265.9°Cat760mmHg
Refractive index:1.534
Flash Point: 114.6°C
Purity: 98%
EINECS: 202-701-9
Purity: 98%
Appearance: white powder
Superiority Buy Phenylboronic acid
items standard result
appearance
white crystalline powder
conforms
assay (hplc) 99.0% min 99.7779%
Phenylboronic acid 95 98-80-6 – Sigma-Aldrich
A14257 Benzeneboronic acid, 98+% – Alfa Aesar
Phenylboronic acid | CAS 98-80-6 | SCBT
Phenylboronic Acid (contains varying amounts of Anhydride)
Phenylboronic Acid (contains varying amounts of Anhydride)
What Is Phenylboronic acid, Cas No 98-80-6 Guide – ECHEMI
Factory supply Phenylboronic/ Boronic acid CAS NO. 864759-63-7, CAS NO. 98-80-6.
Phenylboronic acid | C6H7BO2 – PubChem
Phenylboronic acid 98-80-6 – SRL Chemical
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